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pipeline

ADVANCING A PIPELINE BUILT ON PRECISION

We’re advancing a pipeline built on precision, where each program teaches the next, and every success compounds value.

the pathos development model:
A Smarter System for Clinical Progress

Traditional pipelines progress in phases. Ours accelerates through engines that learn.

Each trial within the PathOS™ platform integrates multimodal data and adaptive AI to refine patient selection, optimize design, and accelerate clinical outcomes.

data-informed

AI-Enabled

AI-Enabled

Clinically Proven

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programs in development

preclinical

phase 1

phase 2

phase 3

Pocenbrodib (CBP/P300 inhibitor)

preclinical

phase 1

phase 2

phase 3

preclinical

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Phase 1

Phase 2

Phase 3

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Indication: Prostate, Multiple Myeloma

Additional Information

DO-2

preclinical

phase 1

phase 2

phase 3

preclinical

phase 1

Phase 2

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Phase 3

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Indication: Non-Small Cell Lung Cancer (NSCLC)

Additional Information

P-100 (previously AZD4241)

preclinical

phase 1

phase 2

phase 3

preclinical

Phase 1

Phase 2

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Phase 3

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Indication: Breast

Additional Information

JSKN016

preclinical

phase 1

phase 2

phase 3

PRECLINICAL

Phase 1

Phase 2

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Phase 3

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Indication: Solid Tumors

Additional Information

*Pathos integrates patient selection data, mechanistic modeling, and trial intelligence into each program — creating a self-improving system that drives both scientific and commercial success.

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The Science Behind Data-Driven Discovery

Our translational research connects molecular mechanisms to real-world outcomes. Pathos collaborates with leading oncology institutions to publish, validate, and refine its platform across tumor types and therapeutic classes.

Abstract 6249: Probabilistic causal network models from real-world prostate cancer data identify potential synergistic combinations with CBP/P300 inhibitors.

scientific publication

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Leveraging probabilistic causal disease models to understand molecular pathways and target resistance mechanisms in Multiple Myeloma with the CREBBP and EP300 bromodomain inhibitor, pocenbrodib.

scientific publication

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Targeting resistance mechanisms to AR-targeted therapy in prostate cancer through inhibition of CREBBP/EP300.

scientific publication

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FT-6876, A Potent and Selective Inhibitor of CBP/p300 with Antitumor Activity in AR-Positive Breast Cancer.

scientific publication

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The Courage Study: A First-In-Human Phase 1 Study of the CBP/p300 Inhibitor FT-7051 in Men With Metastatic Castration-Resistant Prostate Cancer.

scientific publication

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Leveraging probabilistic causal disease models to understand molecular pathways and target resistance mechanisms in Multiple Myeloma with the CREBBP and EP300 bromodomain inhibitor, pocenbrodib.

presentation

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Initial Findings From an Ongoing First-In-Human Phase 1 Study of the CBP/p300 Inhibitor FT-7051 in Men With Metastatic Castration-Resistant Prostate Cancer.

presentation

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A Phase 1 Study of the Protein Arginine Methyltransferase 5 (PRMT5) Brain-Penetrant Inhibitor PRT811 in Patients with Recurrent High-Grade Glioma or Uveal Melanoma.

presentation

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Discovery of PRT811, a potent, selective, and orally bioavailable brain penetrant PRMT5 inhibitor for the treatment of brain tumors.

poster

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A phase 1 dose-escalation study of protein arginine methyltransferase 5 (PRMT5) brain-penetrant inhibitor PRT811 in patients with advanced solid tumors, including recurrent high-grade gliomas.

poster

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FT‑6876, A Potent and Selective Inhibitor of CBP/p300, is Active in Preclinical Models of Androgen Receptor‑Positive Breast Cancer.

poster

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Learn more about the Pathos Platform

Each program teaches the next, advancing a repeatable model for precision drug development that compounds over time.

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